Vitamin B12 injections for MTHFR: Injection or sublingual B12? Methyl Life Supplements Should You Take Natural vs. Synthetic B12? The Advantages of B12 Injections Versus Oral Supplements: Shawn Veiseh, M.D.: Family Medicine Vitamin B12 Forms A vitamin B12 injection is a shot that delivers B12 directly into your muscle, helping your body absorb it quickly (especially if your body struggles to absorb it from food or tablets) Vitamin B12 injections deliver high doses of this essential vitamin directly into your bloodstream for better absorption than oral supplements to boost energy, support red blood cell production and maintain nerve function.