PARACETAMOL (ACETAMINOPHEN) OVERDOSE A SERIOUS RISK Paracetamol ( acetaminophen) is safe when taken as prescribed. Self prescription or overdosing can cause severe liver damage and death. Early symptoms may be mild, but GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity. Toxic doses increase oxidation into NAPQI, overwhelming glutathione. How does ethanol interfere with acetaminophen metabolism? Image: https: t.co 6EY9dIwLXY File:Acetaminophen metabolism.jpg Wikimedia Commons Accidental paracetamol poisoning The Medical Journal of Australia Myra White: OTC Glutathione & Skin Whitening Supplement Why patients taking enzyme Inducers and patients with anorexia nervosa experience higher risk of paracetamol toxicity?? Acetaminophen (Paracetamol) is extensively metabolized by the liver via three main hepatic pathways: glucuronidation, sulfation,