Pharmacokinetics Revise Dental Kinetics Following an Extravascular Dose Basicmedical Key The Absolute Bioavailability, Absorption, Distribution, Metabolism, and Excretion of BI 425809 Administered as an Oral Dose or an Oral Dose with an Intravenous Microtracer Dose of [14C] BI 425809 in Healthy Males Oral bioavailability An ABC of PK PD IC50, EC50, and LD50 help us understand drug potency and effect. Therapeutic Index (TI) indicates drug safety lower TI requires careful monitoring. Bioavailability determines how much drug actually reaches Oral bioavailability An ABC of PK PD