Pyroglutamic acidosis Deranged Physiology Interleukin 4 deficiency protects mice from acetaminophen induced liver injury and inflammation by prevention of glutathione depletion Inflammation Research Springer Nature Link Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Acetaminophen's Role in Autism and ADHD: A Mitochondrial Perspective Good ol' paracetamol: 'But an overconsumption takes its toll' Journal of Anaesthesia Practice