Pigmented macular lip lesion Clinical Advisor Oral melanoma and other pigmentations: when to biopsy? Lambertini 2018 Journal of the European Academy of Dermatology and Venereology Wiley Online Library Mara Ever wondered what those little brown spots are that are often found on the lip? Many refer to them as a freckle but the medical term is melanotic macules. An oral melanotic macule is a harmless dark spot found on the lip, most often the lower lip, or inside the mouth, either on the gums, inside the cheek, or on the roof of the mouth. An oral melanotic Dark Spot on Lip: Harmless or Serious? What to Check First La Bouche Parfaite Labial melanotic macule