Acetaminophen metabolism. Acetaminophen is metabolized primarily by Download Scientific Diagram Clinical toxicity of Acetaminophen Drug Toxicity and Poisoning Basicmedical Key 3 Glutathione Rescue Normally, glutathione binds NAPQI and converts it into non toxic byproducts (cysteine + mercapturic acid) that are excreted. Example: Glutathione is your liver's safety net against toxins. Fasting depletes Glutathione, turning "safe" Paracetamol doses into a liver toxic emergency. Don't let a therapeutic dose become a lethal one. See the safety protocols on BMJ Best Practice via bio. #MedEd # Tox and Hound Fellow Friday What Terror Hath NAPQI Wrought?