What to Avoid When Taking Glutathione Thornhill's Pharmacy Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. The Use and Potential Benefits of N Acetylcysteine in Non Acetaminophen Acute Liver Failure: An Etiology Based Review Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health Tylenol an overview ScienceDirect Topics The biochemistry of acetaminophen hepatotoxicity and rescue: a mathematical model Theoretical Biology and Medical Modelling Springer Nature Link