Moles vs. Freckles: What's the Difference? Western Maryland Dermatology Freckles vs Moles: How to Spot the Difference The Difference Between Sunspots and Freckles and How to Care for Each Ornella Freckles develop when specific skin cells produce extra melanin in response to sunlight. When ultraviolet rays reach the skin, melanocytes release melanin to protect deeper layers from damage. In some How to Tell the Difference Between a Mole and a Freckle Century Medical & Dental Center Sun Spots vs Freckles on Dark Skin What's the Difference? BGS