Best Vitamin B12 Injection Sites: Where to Inject B12 PA Relief A Retired RN About Vitamin B12 Injections How to Give Yourself Intramuscular (IM) Injections Patients & Families UW Health Safe IM Injection Site Intramuscular injection should always be given in the **upper outer quadrant of the gluteal region** to prevent sciatic nerve injury. Key nursing points: Upper outer quadrant = B12 vitamin Store How to inject B12 in your arm Types of Injection Injection is a method of administering medication directly into the body using a needle and syringe. It allows fast and effective absorption of medicines. Intradermal (ID)