Too much paracetamol = dangerous because of how your liver processes it. *Normal dose:* About 90 95% gets broken down safely by glucuronidation + sulfation non toxic stuff you pee out. *The problem Molecular Modelling Analysis of the Metabolism of Paracetamol Interleukin 4 deficiency protects mice from acetaminophen induced liver injury and inflammation by prevention of glutathione depletion Inflammation Research Springer Nature Link Tylenol's Impact on Glutathione and Liver Damage Combination of Paracetamol and the Glutathione Depleting Agent Buthionine Sulfoximine Show Differential Effect on Liver Cancer Cells and Normal Hepatocytes Metabolism of Paracetamol (Acetaminophen), Acetanilide and Phenacetin Medicinal Chemistry PharmaXChange.info