GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity. Toxic doses increase oxidation into NAPQI, overwhelming glutathione. How does ethanol interfere with acetaminophen metabolism? Image: https: t.co 6EY9dIwLXY Glutathione an overview ScienceDirect Topics Glutathione Metabolism an overview ScienceDirect Topics Three amino acids walk into a bar.the adventures of supporting glutathione synthesis in fatty liver disease using serine & nicotinamide riboside Dr. Kara Fitzgerald Figure 3 from Glutathione synthesis. Semantic Scholar LON CAPA KEGG: Glutathione metabolism Standard metabolic pathway