pentose phosphate pathway in biology: Definition, Types and Importance AESL Pentose Phosphate Pathway Biochemistry Flashcards ditki medical and biological sciences A metabolic switch to the pentose phosphate pathway induces radiation resistance in pancreatic cancer Radiotherapy and Oncology HMP also known as the Pentose phosphate pathway. Consists of two irreversible oxidative rxs followed by a series of reversible Pentose Phosphate Pathway made simple. This pathway has two major jobs: Generate NADPH Produce ribose 5 phosphate NADPH protects cells from oxidative stress and supports fatty acid, cholesterol, steroid, nitric oxide, and respiratory burst Pentose phosphate pathway: phases, reactions, & metabolic roles